There are two families in the book Brianna, and both families include a ten-year-old girl who will be featured. The Waterfords and the Millers meet in unusual circumstances and become close friends. The two girls, Brianna and Katrina, become especially close. Both girls have an incurable skin disorder. Both are different but similar in treatment, as are the effects on the girls and their families.
The book deals with having a visible difference at school, bullying, challenges growing up, and the unending treatment of their skin problems. Brianna and Katrina (Kitty) call themselves the Skin Twins.
The story covers three years of Brianna’s life, from when she begins school at eight years old; she’s been homeschooled until then. Kitty joins the story later. The book details surgical aspects of skin grafting and hospital stays and the emotional issues for the two girls and their families.